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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3eac4ef080c2e1898f6327b0de1b1a3c6bccffc99a1eb931147ad4c18c729fb0' 
  AND token = 'GETeO2LRaia8/E75KHiPZ9WMhOZOjnbXWR3F7FNkTqk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}