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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e5de0f331bd71239ede9b1eb56b54b741bdca8b6e4a534c11d2c992821a8a08' 
  AND token = 'wI6l6mEVg79M/DiLCi1XYThpqEZkWAyY/MPKl8LsmPE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}