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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd0a4735988be2965e7d0a85965d7c7e1afd6d2196b871167f31a546f7900138d' 
  AND token = 'RPBEU5vj6yPG72fQKNtaaPjTDVz6uMOSpVSZ1OstDng=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}