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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e3049b6d185a00bfa4965fd31ea115cab0ece3895b47d04704b10843e16909a' 
  AND token = 'HoabpqDuJ6Zm2igQN+FNAnlKGh9OnlXFsXVEJ7DGips=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}