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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e250f6f262b7f9c5df052be09249d5384a40b7e1453b3c08f9e1f5032954ce3' 
  AND token = 'QbBcNZjJRg+047G6EH/xYaGHpA+p0hcBIcwVd3XfOHQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}