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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49c0a3f59757c1a357801d18ec12797125373252ec51c5b83f6d2c7971398fdd' 
  AND token = 'lUAg1BSxeDLx4Sk3jdroWSZVny3YRlg43zWD1QuscvQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}