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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43f28b40dde85edbf05f80e389d2de99e11faaa7d71ee1432ab7eb3ceececdb3' 
  AND token = 'ZFPYScF7Vw5sBj9r/0GUt+EVBltO72uPAJJL5g38GQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}