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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a51e91dc6b1cff6a3afd4aed18ba6968d04d135813f39976b2033aa135ea0b8b' 
  AND token = 'MsCE3LpKohHsmK4cxK3thKrUMWBA52UukfqmZgGNXA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}