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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '859bbd16659ee5970e9f470f12f0a61b474a4ad1da53f5581166a39878321b61' 
  AND token = 'HpXECD2W1nButCROl/fTcKFeN8d4PdM9WJIAjt/njP4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}