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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af22a71eb929fbb81f90129b0065b2032123fbc4316a44d0f74f6cab6ff4dbd1' 
  AND token = 'Nl8y4ATvvQhkenrWVOXFclFL4kQbdWK6D6S2Y9BUpPk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}