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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42817286ddb701fd3ad6e40d2f2eda076a7c3fa246acb3aa4aac7cf726876490' 
  AND token = 'nvqh4f1xHAZqtw5jJt8YSn5E2cMlmkjkli3ox7ZoMKY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}