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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '580b74e7efaf22369203cf5d016a33b0b1f685d9607d3999f47a7562125623b1' 
  AND token = 'TdHKg703N3BklTSiGp+uX0Ic5HfWuwqz7c3gJ3qOPhI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}