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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d51e2b82cbd2634b490f3afce1dcf241f4edc29c500adcb6bc9dbff97836dff' 
  AND token = 'EvwK3KHWlqm63K7ZnFDGfFGP1luAag4+pLe3ilN/wUE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}