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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9375431b4c968e4450ac69edf7b1b5b7a12559ebe4e98fabb5f406f28d15a446' 
  AND token = '00T6Ei/64u4Nb5QcaAYt3bGuxUmUSuHrS8B/5LTqDoU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}