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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '95b6d420e489c024d0b9bf8408137fc46f82ca72ff84f3d2122f31673a388d22' 
  AND token = 'zDDLZXm9vYBxArhnF+JTtAMlCGTGDEN4ebo0mCuIXDk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}