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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '85c3f11748dc430ff5d956adbd4161c2fbf4a062d4ed802628af7528aa968425' 
  AND token = '0o65DXkld5LvxY2mBHPWP4bkmF4DOZQ4vLMFzGcfTlM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}