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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'efc37e7d6e09fbed4807e51395222c43855d521ee6aa1dcf8dd2461b6757c7f4' 
  AND token = 'qewpTqgcU1UsbueiVRURl3f2mekUsspDb3m1Fk/hiNk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}