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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cd45b289afc7b120d7a50b09cad771ebbc1e542e600e898bb4c2745639e6c4c1' 
  AND token = 'JYXuo2GPuEvQYMUjIfdFWzO6wUZGOTa9tenZdx6icCw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}