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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66b798722b4bdb85c61a8433e0942fe2bc013dfc5fe78ed0996dbed3666d1977' 
  AND token = 'GU5URv5rPmZtBT3b1CNmnVnSO7H5PYDkMcRZ2abrXXQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}