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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c14eb4288a215827c5690f327d2f887225a0280566cdce8be95c0ef96f0cdb56' 
  AND token = 'Da/2XoGSgxoiIh7nhzgfCCp0G4qGqYpvycmB6rR35RE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}