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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cc003dc04629b2a9cf1589ee34b9412ffd40b40261359c7d61127967f6503407' 
  AND token = '+txtjMUezgv784HT463OHV+oXirzaMowEdd/+2t31Mo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}