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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4736b82137d1ad6a390b115d1207747efce8cb50f8ba2ba38a99eb76b63493af' 
  AND token = 'Honez/pRJ97vl7i9klj9+YouGWUBHobxZZuiIt61Co0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}