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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '187bd8a44aba0b58cd1890f9c3a6fbfc11cf0db085078c2d09c18c2c09dd3dff' 
  AND token = 'ZFmKD1doQOUFVT89Z26kuzrSajmwB57c29RQRGFn1Co=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}