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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fed25479e394ba0bbfdd149197bd0d963490fecb00b4be4182e3f4d7251cb087' 
  AND token = 'uHRNei4g7R+s80p1xyWSUnzgcUFR0TlqyYgEa3csVpI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}