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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6621f0a44729730e6a9b11d5131da26b6812e13bea66599f4777875d54521c75' 
  AND token = 'kyqC840FfR5oAT+tIEH+g63ShJunuc777M+9lX8MwbE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}