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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74a0e200710f798eee5e78c8fc89a4e3bfe2d96e109c5b333432df0e1e2b0adb' 
  AND token = 'EBpLB+s+l8t5bYp0aMS6lIW3OE/5p3uRz4SAgVDJbmM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}