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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e6724d4661d096ee6bd4409a97328216233806ffa384f8910f3eddc564def38' 
  AND token = 'fF1MiU0xrOtH/k/Bk/5gH0EuX3qcdaAFfhTeiy3LxvY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}