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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65477f781064bdd5ef801e40fa1a1c4acc5a076b98dad1104b4b535b8e22abb8' 
  AND token = 'mNPpNvKUMcp8pKpCOdveKFgs5KPFy77IWwhIsHU9DUQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}