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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e22473f8af71537e3e07728e4f1dc6fe6b90f0c6a94452285f0051b122dde9f' 
  AND token = 'qNMTb3RbHQ1S2+eoAXQctiHSMhA2ljfeHk6ANOdZDsc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}