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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7381c2f8383b5c8ed2ebe31464255f4c3d5d822d0e71e53427c87c6c17733030' 
  AND token = 'As/ms6ZsOApzgyc6ZiyHPKUfkZ/0Ow29CvpT86kxRyU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}