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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e4ec33559a9e0b31b48a8599379f22c02956544979d7ae2e832a4973328dd6a' 
  AND token = 'r/S/VXBE9LuKF0YlaiRzpREuMZzP4JORBOM8jH9SiDQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}