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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '395c27714a9fef15dc14e9ae439e922cbc95f4be4e2ea7f0fc0f94f619c13878' 
  AND token = 'b6aX4M1PdwCDT7VAb1S28xDo0U4m+p7nZL+oFc4A7Q0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}