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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21c1dbf6b69abab6905209e4bb6f061a9b55a74e64092021530a15cb1e45a582' 
  AND token = 'cMqEzZMy+UdXmk/Dj4LEKOtGkG/qPEHPwUjREvQcFy4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}