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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '649bad2a8c407b0214fadb104d565b492ac95f741260dd3e580756d9b1b4a273' 
  AND token = 'BZaoebNa0e8zpGWxPSRYrhHk78lNfxdrH3WHvOqXzcs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}