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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '921c015b4a3a41245287e547f5d7d8d4bac1439cf1d8158b0faa513709b3dedd' 
  AND token = 'aO2oM/gSHHDmo3kH/KRtzWKRCgyijotS7d7bZw7tn6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}