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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9ecfa7a4e721be7e2c54dd4c1d69c876883b59769422ebc92f603df80ccf3f24' 
  AND token = 'JOaa7OYdxVdmIpiioShkIeIg+7u8IHvjjNHZv27Atd4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}