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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '715b05de4a7a4241bc0303b549b28c2b59c68a159f5e51d432285b300e3cb485' 
  AND token = '3fcE1tHB2BqD4cnwhW+gbbMwHQMLD16PDZHnvn7shI4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}