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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2d780627d2c5d0a71b442113bd873a1db8dbf72d0cb1ca858cc50b329a63ea2' 
  AND token = 'yOzE+eLJKfQKXPGxsNpyjc+oq3RoAOxliBe0uG4sSpA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}