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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b143c26b50381f15b5b2fdf80d4291c241028ffe6fefc87a5b4be1a50dc28865' 
  AND token = 'OpYgG81wXaEizZJexF+JBHmCXB0hN9QG00bRdy38Pjk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}