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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a1d8a4f3a760060ed5f8e9bb4d00a81c0d8498cf917ec26f97d232244795b9f' 
  AND token = '1ZdAS/2u0tvSiMDK0caKQS0VqqD+XfNC1hIckjFtgNk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}