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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8fc45946c9274f840d928bfa4d309495483032f781eb659ee11fc8d7f5135c6' 
  AND token = 'ksqD+NbAPv8+3l7OLUq8i06Q5ObcGoNyuN2jdoRwe10=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}