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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '451ed92e492b7ca2be39654197e9d40d2dbf4fcddd7ec1574af009b7a0be3231' 
  AND token = 'ykq6AMEpfhHpZtAZW/wKLRw06pzFrivzayADnR4q3ts=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}