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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d5317d22bc2e556225fc8a75b21671a35186dfe2946a9b8a225e0f820c220b7' 
  AND token = '0/QWlmKUKsvt9TEZLg1C5OyDU+TiNG4lrRDjRDtFaAg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}