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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18772e4b72e9da67a21fcd74f2e8c004b65742f9385a153f4f3320ead744f9cb' 
  AND token = 'K49qxCzZf1lX3t2ofAVhxkZkU+8oEXiYQln8InD6cj8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}