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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e1c1a9557836b69cf63bf1bf63ac9b958d51cfb346a403b4ea988fd75c0c379' 
  AND token = 'ThLZRA3wAN2n4ua4tMFytt9Lyic86Hz7z2dShzKHih4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}