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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3bf4e8c061e67494ed1d6831245e80a18989a3dfe5d409e7d2283db021da0b75' 
  AND token = 'VM5KPs6HIJG+Tc7X1IjWUuSfehoM4RYrcY6FzUiak/8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}