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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7cb66152093bb6365a1b631a92c7b2fdef81a2e5020a4e2662cb9d83f910c6b0' 
  AND token = 'zxt9YNOTy2YBh3Zdy8hbJ+wfEi+qSPrNZZTku66AFzw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}