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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49aa8ab1a66efd87a78e2645a5e5f329041c0c86ff65a433ed89238a542300f2' 
  AND token = 'wnfRM1Ugb6ySyWwF5sY73XCpEed88/HT9RZtvJe3z8k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}