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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd251db6f5299b256c0a0affeb0567a7909bf8a64397cf9924ad17ed673f00cf7' 
  AND token = 'N7XVFm/bWrsXoxcsBQn5CxY7TKYbHuBEjJOZ6euWc6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}