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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d3b84556c5ee8ec435eb586b2c38845ce5855be613e558ab1094028fd977199' 
  AND token = '754xZO6Wp0rZjz8KAWoVf/Eef2OW5+FUuiYF2BDsuk0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}